• Air Bubbles Activate Complement and Trigger Hemostasis and C3-Dependent Cytokine Release Ex Vivo in Human Whole Blood 

      Storm, Benjamin; Christiansen, Dorte; Fure, Hilde; Ludviksen, Judith K; Lau, Corinna; Lambris, John D.; Woodruff, Trent M.; Brekke, Ole-Lars; Braaten, Tonje Bjørndal; Nielsen, Erik Waage; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-03)
      Venous air embolism, which may complicate medical and surgical procedures, activates complement and triggers thromboinflammation. In lepirudin-anticoagulated human whole blood, we examined the effect of air bubbles on complement and its role in thromboinflammation. Whole blood from 16 donors was incubated with air bubbles without or with inhibitors of C3, C5, C5aR1, or CD14. Complement activation, ...
    • Associations Between Self-Rated Health and Mortality in the Norwegian Women and Cancer (NOWAC) Study 

      Killie, Ida Løken; Braaten, Tonje Bjørndal; Lorem, Geir Fagerjord; Borch, Kristin Benjaminsen (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-20)
      Purpose: We investigated the association between self-rated health (SRH) and cancer incidence and SRH and all-cause mortality among Norwegian women.<p> <p>Population and Methods: We used data from 110,104 women in the Norwegian Women and Cancer (NOWAC) cohort aged 41– 70 years at baseline. We used flexible parametric survival analysis with restricted cubic splines to calculate hazard ratios (HRs) ...
    • Blood Volume, Hemoglobin Mass, and Peak Oxygen Uptake in Older Adults: The Generation 100 Study 

      Lundgren, Kari Margrethe; Aspvik, Nils Petter; Langlo, Knut Asbjørn Rise; Braaten, Tonje Bjørndal; Wisløff, Ulrik; Stensvold, Dorthe; Karlsen, Trine (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-01)
      <p>Purpose: To investigate the association between blood volume, hemoglobin mass (Hb<sub>mass</sub>), and peak oxygen uptake (VO<sub>2peak</sub>) in healthy older adults. <p>Methods: Fifty fit or unfit participants from the prospective randomized Generation 100 Study (<i>n</i> = 1,566) were included (age- and sex-specific VO<sub>2peak</sub> above or below average values). Blood, plasma, and erythrocyte ...
    • Combined Lifestyle Behaviors and the Incidence of Common Cancer Types in the Norwegian Women and Cancer Study (NOWAC) 

      Chen, Sairah Lai Fa; Braaten, Tonje Bjørndal; Borch, Kristin Benjaminsen; Ferrari, Pietro; Sandanger, Torkjel M; Nøst, Therese Haugdahl (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-16)
      <i>Introduction</i>: Only a small number of studies have examined the impact of combined lifestyle behaviors on cancer incidence, and never in a Norwegian population.<br><br> <i>Purpose</i>: To examine linear and nonlinear associations of combined lifestyle factors, assessed through a healthy lifestyle index (HLI), with the incidence of postmenopausal breast, colorectal, lung, postmenopausal ...
    • Feasibility of a new intervention addressing group-based balance and high-intensity training, physical activity, and employment in individuals with multiple sclerosis: a pilot randomized controlled trial 

      Arntzen, Ellen Christin; Braaten, Tonje Bjørndal; Fikke, Hanne Kristin; Normann, Britt (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-08)
      Background and purpose: Impaired sensorimotor function, reduced physical activity and unemployment are common challenges in persons with multiple sclerosis (pwMS), even when disability is low. CoreDISTparticipation is a new, multidisciplinary intervention delivered across healthcare levels systematically addressing these elements. This study primarily aimed to evaluate the feasibility ...
    • Labour market status and mortality risk: the Finnmark cohort study 1987–2017 

      Dybdahl Jakobsen, Monika; Braaten, Tonje Bjørndal (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-19)
      Aims: The aim of this study was to investigate the age-varying mortality risk associated with different labour market status categories.<p> <p>Methods: Data from a population-based survey carried out among adults aged 30–62 years in Finnmark in 1987/1988 were linked to the Norwegian Cause of Death Registry to identify all deaths occurring by December 2017. We used flexible parametric survival ...
    • Lifestyle risk factors of self-reported fibromyalgia in the Norwegian Women and Cancer (NOWAC) study 

      Benebo, Faith Owunari; Lukic, Marko; Jakobsen, Monika Dybdahl; Braaten, Tonje Bjørndal (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-11)
      Background While the aetiology of fibromyalgia syndrome (FM) remains unknown, lifestyle factors have been linked to the disorder. However, there are few studies on the association between lifestyle factors and FM, thus we examine the risk of self-reported fibromyalgia given selected lifestyle factors.<p> <p>Methods We used data from 75,485 participants in the Norwegian Women and Cancer study. ...
    • Midwives and public health nurses' knowledge and clinical practice in securing sufficient iodine status in relation to pregnancy. A cross-sectional study 

      Johnsen, Maren; Braaten, Tonje Bjørndal; Skeie, Guri; Laholt, Hilde; Hansen, Solrunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-25)
      Aim - To investigate midwives' (MWs) and public health nurses' (PHNs) clinical practice and knowledge related to nutrition, with a particular focus on iodine in northern parts of Norway. Maternal iodine status prior to and during pregnancy, and the lactating period, is crucial for brain development and growth of the foetus and infant, from conception up until the first two years of life. In Norway, ...
    • Never-smokers and the fraction of breast cancer attributable to second-hand smoke from parents during childhood: the Norwegian Women and Cancer Study 1991–2018 

      Gram, Inger Torhild; Wiik, Arne Bastian; Lund, Eiliv; Licaj, Idlir; Braaten, Tonje Bjørndal (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-01)
      Background - Second-hand smoke (SHS) is not an established risk factor for breast cancer. We examined exposure to SHS from parents during childhood and breast-cancer risk overall and by oestrogen- and progesterone-receptor status in the Norwegian Women and Cancer Study. Furthermore, we utilized our nationally representative prospective cohort study to estimate the fraction of breast cancer attributable ...
    • Non‑linear associations between healthy Nordic foods and all‑cause mortality in the NOWAC study: a prospective study 

      Jensen, Torill Miriam Enget; Braaten, Tonje Bjørndal; Jacobsen, Bjarne Koster; Skeie, Guri (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-25)
      Background: The shape of the associations between intake of foods basic in a healthy Nordic diet and long-term health is not well known. Therefore, we have examined all-cause mortality in a large, prospective cohort of women in Norway in relation to intake of: Nordic fruits and vegetables, fatty fsh, lean fsh, wholegrain products, and low-fat dairy products.<p> <p>Methods: A total of 83 669 women ...
    • Open chest and pericardium facilitate transpulmonary passage of venous air emboli 

      Storm, Benjamin; Halvorsen, Per Steinar; Skulstad, Helge; Dybwik, Knut Gustav; Schjalm, Camilla; Christiansen, Dorte; Wisløff-Aase, Kristin; Fosse, Erik; Braaten, Tonje Bjørndal; Nielsen, Erik Waage; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-17)
      <p><i>Background:</i> Transpulmonary passage of air emboli can lead to fatal brain- and myocardial infarctions. We studied whether pigs with open chest and pericardium had a greater transpulmonary passage of venous air emboli than pigs with closed thorax. <p><i>Methods:</i> We allocated pigs with verified closed foramen ovale to venous air infusion with either open chest with sternotomy and opening ...
    • Replacing red and processed meat with lean or fatty fish and all-cause and cause specific mortality in Norwegian women. the Norwegian Women and Cancer Study (NOWAC): A prospective cohort study 

      Jensen, Torill Miriam Enget; Braaten, Tonje Bjørndal; Jacobsen, Bjarne K.; Ibsen, Daniel B.; Skeie, Guri (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-11)
      Nordic Nutrition Recommendations recommend reducing red and processed meat and increasing fish consumption, but the impact of this replacement on mortality is understudied. This study investigated the replacement of red and processed meat with fish in relation to mortality. Of 83 304 women in the Norwegian Women and Cancer Study (NOWAC) study, 9420 died during a median of 21·0 years of follow-up. ...
    • Reproductive and hormonal factors and risk of renal cell carcinoma among women in the European Prospective Investigation into Cancer and Nutrition 

      Clasen, Joanna L.; Mabunda, Rita; Heath, Alicia K.; Kaaks, Rudolf; Katzke, Verena; Schulze, Matthias B.; Birukov, Anna; Tagliabue, Giovanna; Chiodini, Paolo; Tumino, Rosario; Milani, Lorenzo; Braaten, Tonje Bjørndal; Gram, Inger Torhild; Lukic, Marko; Luján-Barroso, Leila; Rodriguez-Barranco, Miguel; Chirlaque, María-Dolores; Ardanaz, Eva; Amiano, Pilar; Manjer, Jonas; Huss, Linnea; Ljungberg, Börje; Travis, Ruth; Smith-Byrne, Karl; Gunter, Marc; Johansson, Matthias; Rinaldi, Sabina; Weiderpass, Elisabete; Riboli, Elio; Cross, Amanda J.; Muller, David C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-03)
      Background - Renal cell carcinoma (RCC) is twice as common among men compared with women, and hormonal factors have been suggested to partially explain this difference. There is currently little evidence on the roles of reproductive and hormonal risk factors in RCC aetiology.<p> <p>Materials & Methods - We investigated associations of age at menarche and age at menopause, pregnancy-related factors, ...
    • Seroprevalence of antibodies against SARS-CoV-2 in the adult population during the pre-vaccination period, Norway, winter 2020/21 

      Anda, Erik Eik; Braaten, Tonje Bjørndal; Borch, Kristin Benjaminsen; Nøst, Therese Haugdahl; Chen, Sairah Lai Fa; Lukic, Marko; Lund, Eiliv; Forland, Frode; Leon, David Andrew; Askeland Winje, Brita; Kran, Anne-Marte Bakken; Kalager, Mette; Lund-Johansen, Fridtjof; Sandanger, Torkjel M (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-31)
      Background: Since March 2020, 440 million people worldwide have been diagnosed with COVID-19, but the true number of infections with SARS-CoV-2 is higher. SARS-CoV-2 antibody seroprevalence can add crucial epidemiological information about population infection dynamics. Aim: To provide a large population-based SARS-CoV-2 seroprevalence survey from Norway; we estimated SARS-CoV-2 seroprevalence before ...
    • Symptoms and signs of urogenital cancer in primary care 

      Holtedahl, Knut Arne; Borgquist, Lars; Donker, Gé A.; Buntinx, Frank; Weller, David; Campbell, Christine; Månsson, Jörgen; Hammersley, Victoria; Braaten, Tonje Bjørndal; Parajuli, Ranjan (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-26)
      Background - Urogenital cancers are common, accounting for approximately 20% of cancer incidence globally. Cancers belonging to the same organ system often present with similar symptoms, making initial management challenging. In this study, 511 cases of cancer were recorded after the date of consultation among 61,802 randomly selected patients presenting in primary care in six European countries: a ...
    • Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis 

      Morales-Berstein, Fernanda; Biessy, Carine; Viallon, Vivian; Goncalves-Soares, Ana; Casagrande, Corinne; Hémon, Bertrand; Kliemann, Nathalie; Cairat, Manon; Blanco Lopez, Jessica; Al Nahas, Aline; Chang, Kiara; Vamos, Eszter; Rauber, Fernanda; Bertazzi Levy, Renata; Barbosa Cunha, Diana; Jakszyn, Paula; Ferrari, Pietro; Vineis, Paolo; Masala, Giovanna; Catalano, Alberto; Sonestedt, Emily; Borné, Yan; Katzke, Verena; Bajracharya, Rashmita; Agnoli, Claudia; Guevara, Marcela; Heath, Alicia; Radoï, Loredana; Mancini, Francesca; Weiderpass Vainio, Elisabete; Huerta, José María; Sánchez, María-José; Tjønneland, Anne; Kyrø, Cecilie; Schulze, Matthias B.; Skeie, Guri; Lukic, Marko; Braaten, Tonje Bjørndal; Gunter, Marc; Millett, Christopher; Agudo, Antonio; Brennan, Paul; Borges, M. Carolina; Richmond, Rebecca C.; Richardson, Tom G.; Davey Smith, George; Relton, Caroline L.; Huybrechts, Inge (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-22)
      Purpose - To investigate the role of adiposity in the associations between ultra-processed food (UPF) consumption and head and neck cancer (HNC) and oesophageal adenocarcinoma (OAC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.<p> <p>Methods - Our study included 450,111 EPIC participants. We used Cox regressions to investigate the associations between the ...